Note: the concentration profiles and the Cmax, AUC, and Tmax values below are based on total plasma concentrations in peripheral venous blood (i.e. bound plus unbound drug), which is the quantity typically reported in clinical pharmacokinetic studies.
Note: the concentration profiles and the Cmax, AUC, and Tmax ratios below are based on total plasma concentrations in peripheral venous blood (i.e. bound plus unbound drug), which is the quantity typically reported in clinical pharmacokinetic studies.
About This Application
Overview
This application is a specialized platform for simulating Drug-Drug Interactions (DDIs) involving oral contraceptives. It allows users to thoroughly define clinical trial setups, including target populations, specific compounds (both oral contraceptives and DDI precipitants), and the overall study design. To power these analyses, the application leverages Open Systems Pharmacology (OSP) to create and run robust Physiologically-Based Pharmacokinetic (PBPK) simulations.
Scientific Rationale
Standard approaches to evaluating DDIs often assume that changes in drug exposure directly dictate clinical efficacy across different progestins. However, recent evaluations demonstrate that DDI-induced changes in exposure do not directly translate into clinical response. Because of this, DDIs with combined oral contraceptives must be interpreted within a comprehensive pharmacokinetic/pharmacodynamic (PK/PD) context rather than relying on PK data alone. This application provides the quantitative framework necessary to conduct these deeper, more accurate evaluations.
Who is this for?
This platform is designed for clinicians, researchers, and anyone interested in understanding how advanced computational modeling can be utilized to guide drug development, evaluate efficacy, and enhance patient safety.
Key Features
- Import and explore compound models from the OSP model library
- Design DDI simulations between object and precipitant compounds
- Configure dosing protocols (oral, IV bolus, IV infusion)
- Define population parameters and individual characteristics
- Run simulations and analyze results with interactive plots
- Export simulation results for further analysis in PK-Sim
Credits
Developed by ESQlabs GmbH
Authors:
Felix MIL (Author, Maintainer)
Sia Mirza (Author, Contributor)
Diane Lefaudeux (Contributor, Maintainer)
Version: 0.2.1.9010
License: MIT